RALPH H. FORRESTER; JOSE M. LOURO
In 1960, Nowell and Hungerford (1) described a chromosome change in chronic granulocytic leukemia which has since been confirmed by numerous workers and termed the Philadelphia chromosome (Ph1) abnormality. It consists of a loss either by deletion or translocation of approximately half of the genetic material occupying the long arms of one of the small acrocentric chromosomes. The change is illustrated schematically in Figure 1. Chromosome abnormalities of many types have been observed in leukemia (2, 3). There have been too many chromosomes, too few, and a variety of qualitative abnormalities (4). The Ph1 has been unique in that it
FORRESTER RH, LOURO JM. Philadelphia Chromosome Abnormality in Agnogenic Myeloid Metaplasia. Ann Intern Med. ;64:622–627. doi: 10.7326/0003-4819-64-3-622
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Published: Ann Intern Med. 1966;64(3):622-627.
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