JOHN D. DAVIDSON, M.D.; EDWARD P. FLYNN, M.D.; JOEL B. KIRKPATRICK, M.D.
The syndrome of protein-losing enteropathy has become well known since the first definitive demonstration that protein can be lost into the gut (1, 2). The now voluminous literature on this subject reveals that a variety of diseases can be associated with this phenomenon and that the pathogenetic mechanisms of protein loss are multiple.
Intestinal lymphangiectasia as a cause of protein loss into the gut has been described by Waldmann and associates (3). In this condition dilated lacteals in the intestinal mucosa and dilated lymphatics in the mesentery are present, and the rupture of these thin-walled channels leads to protein loss.
DAVIDSON JD, FLYNN EP, KIRKPATRICK JB. Protein-losing Enteropathy and Intestinal Bleeding: The Role of Lymphatic-Venous Connections. Ann Intern Med. 1966;64:628–635. doi: https://doi.org/10.7326/0003-4819-64-3-628
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Published: Ann Intern Med. 1966;64(3):628-635.
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