WILLIAM BELL, M.D.; RAYMOND BAHR, M.D.; THOMAS A. WALDMANN, M.D.; PAUL P. CARBONE, M.D.
In 1955, Korst and Kratochvil (1) reported a patient with a pulmonary neoplasm and thrombophlebitis migrans in whom a cold-preciptable fibrinogen (cryofibrinogen) was detected. Subsequently, cryofibrinogenemia has been described as a primary (idiopathic) and more frequently as a secondary disorder (2). Primary (2) and secondary (3) cryofibrinogenemia may be associated with cold intolerance, Raynaud's phenomenon, and acrocyanosis. In the secondary disorder, thrombo-embolic occlusive phenomena and hemorrhagic diatheses are common.
The present report concerns a patient with a primary hepatoma and markedly elevated plasma levels of fibrinogen and cryofibrinogen. These findings were not associated with any thrombotic or bleeding disorders or
BELL W, BAHR R, WALDMANN TA, et al. Cryofibrinogenemia, Multiple Dysproteinemias, and Hypervolemia in a Patient with a Primary Hepatoma. Ann Intern Med. 1966;64:658–664. doi: 10.7326/0003-4819-64-3-658
Download citation file:
Published: Ann Intern Med. 1966;64(3):658-664.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use