KENNETH D. ROSE, M.D.
Although much has been written concerning the various histological, biochemical, and serological manifestations of infectious mononucleosis (1), there is very little published on the serum protein variations associated with this disease. Sterling (2) studied seven cases by microcell electrophoresis, reporting a diminution of serum albumin (60.3 to 49.9%) and an elevation of the gamma globulins (13.2 to 19.0%). Less pronounced and less frequent were alpha-1 and beta globulin elevations. Hepatic involvement is common, essentially universal, in infectious mononucleosis (1, 3-5). Sterling (2), observing this in six of his seven patients, suggested that the dysproteinemia might be associated with disturbed hepatocellular
ROSE KD. Serum Proteins in Infectious Mononucleosis. Ann Intern Med. ;64:826–833. doi: 10.7326/0003-4819-64-4-826
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Published: Ann Intern Med. 1966;64(4):826-833.
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