JOHN F. MURRAY, M.D.
Studies on the mechanisms that control erythropoiesis have revealed that inadequate oxygenation is a potent stimulus that increases erythrocyte production. Although recent investigations indicate that other factors are also important (1), the common denominator for a variety of experimental and clinical conditions that affect red cell formation is the relationship between the metabolic needs of an organism and the oxygen available to meet these requirements; these observations have led to the oxygen supply and demand theory for the regulation of erythropoiesis (2). The means by which relative oxygen insufficiency leads to increased erythropoiesis are not clear, but implicit in the
MURRAY JF. Classification of Polycythemic Disorders: With Comments on the Diagnostic Value of Arterial Blood Oxygen Analysis. Ann Intern Med. 1966;64:892–903. doi: 10.7326/0003-4819-64-4-892
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Published: Ann Intern Med. 1966;64(4):892-903.
Hematology/Oncology, Red Cell Disorders.
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