JOHN N. BICKERS, M.D.
A substantial percentage of patients with homozygous hemoglobin S disease produce detectable amounts of alkali-resistant hemoglobin* during their adult life. The alkali-resistant hemoglobin lacks the pathologic physical properties of hemoglobin S; thus, the capacity to produce alkali-resistant hemoglobin is of potential importance as a source of functionally normal hemoglobin in sickle cell disease. The recognition of factors that affect alkali-resistant hemoglobin production may provide insight into the basic mechanisms that control its synthesis.
The literature contains remarkably little information on the natural history of alkali-resistant hemoglobin in sickle cell disease and even less concerning the variables that affect its production.
BICKERS JN. Alkali-resistant Hemoglobin in Sickle Cell Disease. Ann Intern Med. 1966;64:1028–1033. doi: https://doi.org/10.7326/0003-4819-64-5-1028
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Published: Ann Intern Med. 1966;64(5):1028-1033.
Hematology/Oncology, Red Cell Disorders.
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