STUART LEVIN; M. B. PAINTER
Acute meningococcal disease has long been recognized as a recurrent problem in closed populations and in the pediatric age group. The sulfonamides have generally been considered the drugs of choice, both for prophylaxis and therapy of this disease (1-5). Penicillin has been used therapeutically in combination with sulfonamides but has not received any recent extensive controlled clinical trial as the sole antibacterial agent in treatment of severe meningococcal disease in adults.
Meningococcal disease has shown a cyclic increase in frequency at roughly 10-year intervals during this century (2, 6), and this organism was a major cause of military deaths due
LEVIN S, PAINTER MB. The Treatment of Acute Meningococcal Infection in Adults: A Reappraisal. Ann Intern Med. ;64:1049–1056. doi: 10.7326/0003-4819-64-5-1049
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Published: Ann Intern Med. 1966;64(5):1049-1056.
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