Charles L. Lyford, B.S.; William E. Connor, M.D., F.A.C.P.; John C. Hoak, M.D. (Associate); Emory D. Warner, M.D.
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Thrombosis associated with severe atherosclerosis usually occurs when ulcerated lesions are exposed to the circulating blood. Conflicting results have been reported concerning the coagulant properties of atheromatous plaque material. In the present study, the effects of atheromatous plaque material upon blood coagulation and platelet aggregation were studied in detail.
The gruel-like plaque material was prepared from human aortas and coronary arteries with severe atherosclerosis obtained at autopsy. Atheromatous material was separated from the endothelium and media and emulsified in 0.9% sodium chloride. The final concentration of atheroma used in the tests was 2% by weight. Human venous blood for clotting
Lyford CL, Connor WE, Hoak JC, et al. The Coagulant and Thrombogenic Properties of Human Atheroma.. Ann Intern Med. 1966;64:1152. doi: https://doi.org/10.7326/0003-4819-64-5-1152_2
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Published: Ann Intern Med. 1966;64(5):1152.
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