E. Clinton Texter Jr., M.D., F.A.C.P.; Roncos Abella, M.D.; Higino C. Laureta, M.D.; Francesco del Greco, M.D.; Ching-Chung Chou, M.D.
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Certain synthetic analogues of vasopressin have been shown to have different pharmacologic effects. The effects related to the circulation may have clinical implications. In the present study the effect of octapressin (PLV-2) upon various regional vascular beds was compared to that of vasopressin. The experiments were performed in 42 dogs under pentobarbital anesthesia. Octapressin and vasopressin were administered at doses of 0.005 to 0.01 units/ml and 0.05 to 0.1 units/ml, respectively, by constant infusion into the superior mesenteric, left gastric, splenic, and renal arteries. Total resistance expressed in units of peripheral resistance was estimated for all vascular beds (J. Lab.
Texter EC, Abella R, Laureta HC, del Greco F, Chou C. Differential Effects of Vasopressin and Phenylalanine2 Vasopressin on Regional Vascular Resistance and Renal Function.. Ann Intern Med. ;64:1153. doi: 10.7326/0003-4819-64-5-1153_2
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Published: Ann Intern Med. 1966;64(5):1153.
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