Carl S. Alexander, M.D., F.A.C.P.
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Myocardium was obtained by needle biopsy from 43 patients with alcoholic heart disease and from one with idiopathic nonalcoholic heart disease. Electron microscopic observations in alcoholic heart disease revealed changes believed to be characteristic for this condition. These include fragmentation and loss of myofibrils, edema sufficient at times to cause cystic dilatation of sarcoplasmic reticulum or cisternae, lipid accumulation and fibrosis. The most striking changes involved the mitochondria which were swollen, increased in number, and showed evidence of degeneration, suggesting a disturbance in formation or release of energy. Mitochondrial changes were not observed in the nonalcoholic heart or in
Alexander CS. Electron Microscopic Changes in Myocardium of Alcoholic Heart Disease.. Ann Intern Med. 1966;64:1154. doi: https://doi.org/10.7326/0003-4819-64-5-1154_2
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Published: Ann Intern Med. 1966;64(5):1154.
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