Alfred M. Dashe, M.D.; David H. Solomon, M.D., F.A.C.P.; Robert W. Rand, M.D.; Josiah Brown, M.D.; S. Douglas Frasier, M.D.
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Stereotaxic transnasal, transphenoidal cryoblation was performed in seven patients with pituitary adenomas causing symptomatic acromegaly. The pituitary tumors were proved by needle biopsy prior to freezing. Roentgen therapy had had little or no effect upon the disease in all seven patients. Preoperative serum growth hormone levels were significantly elevated and were not glucose-suppressible in the six subjects tested. Postoperative levels were remarkably reduced in all seven patients, conforming in general to the subjective and objective clinical improvement postoperatively. The operation was free of significant morbidity in all patients. Anterior pituitary function was maintained in five out of the seven patients;
Dashe AM, Solomon DH, Rand RW, Brown J, Frasier SD. Cryohypophysectomy for Acromegaly.. Ann Intern Med. 1966;64:1159. doi: 10.7326/0003-4819-64-5-1159_1
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Published: Ann Intern Med. 1966;64(5):1159.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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