Maurice M. Pechet, M.D., Ph.D.; Heinz F. Kohler, Ph.D.
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The results of our studies of thyrocalcitonin action indicate that thyrocalcitonin inhibits bone resorption. Thyrocalcitonin was isolated from thyroids of freshly slaughtered hogs and purified extensively so that in the intact rat, 50 µg of purified thyrocalcitonin caused a decrease within 1 hour in serum calcium of 2.2 mg/100 ml and in serum phosphates of 1.1 mg/100 ml. The mechanism of this action on serum calcium and phosphates was investigated in special, single, unanesthetized rat preparations. Constant infusions of dextrose, sodium chloride and potassium chloride were maintained through indwelling gastric and venous catheters. Urine was collected at 30-minute intervals over
Pechet MM, Kohler HF. The Mechanism of Thyrocalcitonin Action: Inhibition of Bone Resorption.. Ann Intern Med. 1966;64:1159–1160. doi: https://doi.org/10.7326/0003-4819-64-5-1159_3
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Published: Ann Intern Med. 1966;64(5):1159-1160.
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