Herbert A. Selenkow, M.D., F.A.C.P.; Marvin S. Wool, M.D.
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Thyroid hormones of animal origin have been used extensively for over 75 years despite several major therapeutic shortcomings. The United States Pharmacopeia (USP) requirements for pharmacologic standardization do not insure uniform hormonal content and thus different preparations of equal iodine content may have widely differing potencies. Synthetic L-thyroxine and L-triiodothyronine each have the distinct advantage of chemical purity but neither simulates all the physiologic actions of endogenous thyroid. L-thyroxine has a prolonged evanescent physiologic action and produces levels of protein-bound iodine (PBI) that are disproportionately high. Conversely, L-triiodothyronine has a rapid, brisk action and gives PBI levels that are quite
Selenkow HA, Wool MS. The Pharmacologic Basis of Thyroid Hormone Therapy.. Ann Intern Med. ;64:1160. doi: 10.7326/0003-4819-64-5-1160_1
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Published: Ann Intern Med. 1966;64(5):1160.
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