George E. Shambaugh III; William R. Beisel
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Acute infection induces storm in thyrotoxicosis or coma in myxedema. Reported alterations in thyroid function during acute infection in humans are limited to a fall in basal metabolic rate, a possible reduction in thyroxine-binding prealbumin (TBPA), but an unaltered disappearance rate of triiodothyronine. To investigate systematically the changes in thyroid physiology during generalized infection, a number of specific studies were carried out using as an experimental model the rat infected subcutaneously with a virulent type I-A-5 pneumococcus.
Depression of thyroid gland function was evidenced by impaired uptake and release of 131I and a fall in serum protein-bound iodine. Neither uptake
Shambaugh GE, Beisel WR. Thyroid Physiology During Generalized Infection.. Ann Intern Med. 1966;64:1160–1161. doi: https://doi.org/10.7326/0003-4819-64-5-1160_3
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Published: Ann Intern Med. 1966;64(5):1160-1161.
Endocrine and Metabolism, Infectious Disease, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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