Leo L. Stolbach, M.D.; Melvin J. Krant, M.D.; Susan C. Sebestyen, M.D.; Norma I. Inglis, A.B.; William H. Fishman, Ph.D.
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A number of isoenzymes of alkaline phosphatase have been found in human serum, and it has been assumed that liver and bone are the main tissue sources of these enzymes. A serum alkaline phosphatase of intestinal origin has now been identified by (1) its characteristic inhibition of enzyme activity in the presence of L-phenylalanine and (2) its location as a band of activity, after starch gel electrophoresis, migrating to the position for purified intestinal alkaline phosphatase. A similar band (unidentified as to organ source) has been related to the ABO blood types of normal individuals by other workers.
Stolbach LL, Krant MJ, Sebestyen SC, et al. Correlation of Serum Alkaline Phosphatase of Intestinal Origin with the ABO Blood Group of Cirrhotics.. Ann Intern Med. 1966;64:1161–1162. doi: https://doi.org/10.7326/0003-4819-64-5-1161_3
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Published: Ann Intern Med. 1966;64(5):1161-1162.
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