Arthur J. Seaman, M.D., F.A.C.P.; C. Lawrence Lutcher, M.D.; Charlotte Mofft; Bonita Hueber
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A new experimental technique, the living extracorporeal eye (Seaman and associates: Clin. Res. 13: 138, 1965 (Abstract); Scand. J. Clin. Lab. Invest. Supplement 84, 17: 101, 1965) is used to study blood flow and thromboembolic phenomena. Bovine eyes are enucleated immediately after slaughter. The ciliary artery is catheterized. The retinal circulation is cleared with modified Krebs' solution. Perfusion with compatible oxygenated human or bovine blood is commenced and recorded with still and cinephotography.
Upon addition of adenosine diphosphate to the heparinized arterial inflow, grossly visible platelet aggregates appear. These visible emboli impede flow and may adhere to the intima. They
Seaman AJ, Lutcher CL, Mofft C, Hueber B. Direct Observation of Induced Intravascular Thromboembolic Phenomena in the Living Extracorporeal Eye.. Ann Intern Med. ;64:1163. doi: 10.7326/0003-4819-64-5-1163_2
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Published: Ann Intern Med. 1966;64(5):1163.
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