Leonard J. Stutman, M.D.; George Y. Shinowara, Ph.D.
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Thrombosis and an increased rate of hemolysis are major features of SS sickle cell disease. Previous investigations from this laboratory have implicated the release of erythrocyte lipoprotein and the increased rate of hemolysis in sickle cell crisis. Lipoprotein complexes were isolated from blood drawn via the citrate-in-syringe technique from five normal people, five people with sickle cell (SS) disease, one person with SC disease, and three essential hyperlipemics. The blood was centrifuged at 1,650 times gravity for 30 minutes at 1 C, and subsequently the red cells were washed three times at 1 C with buffered saline, pH 7.4. Aliquots
Stutman LJ, Shinowara GY. The Effect of Erythrocyte Lipoprotein Complexes on Thromboplastin Generation in Normal and Diseased States.. Ann Intern Med. 1966;64:1163–1164. doi: https://doi.org/10.7326/0003-4819-64-5-1163_3
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Published: Ann Intern Med. 1966;64(5):1163-1164.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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