Robert E. Rubin, M.D.; Harvey Gralnick, M.D.; Julian Niemetz, M.D.; Solomon Estren, M.D., F.A.C.P.; Louis E. Wasserman, M.D., F.A.C.P.
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The patient with hemophilia and a circulating anticoagulant often represents a grave medical emergency not responsive to therapy with fresh frozen plasma, since the anticoagulant blocks the action of antihemophiliac globulin (AHG). Concentrates of AHG of animal origin afford a therapeutic approach which has not been previously reported in this country.
We have studied four patients with circulating anticoagulants directed against AHG, three of whom were known hemophiliacs. The fourth did not have hemophilia, but, at age 62, was found to have a circulating anticoagulant directed against AHG. Three of these patients developed, at various times, severe life-threatening pharyngeal hemorrhages,
Rubin RE, Gralnick H, Niemetz J, Estren S, Wasserman LE. The Use of Animal AHG-Concentrates in Patients with Circulating Anticoagulants.. Ann Intern Med. 1966;64:1165. doi: 10.7326/0003-4819-64-5-1165_3
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Published: Ann Intern Med. 1966;64(5):1165.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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