Jaime F. Bravo, M.D.; Jerome H. Herman, M.D.; Charley J. Smyth, M.D., F.A.C.P.
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Of 55 patients receiving renal homotransplantation whose duration of survival (mean, 506 days) permitted accurate analysis, one or more clinical manifestations denoting connective tissue disorder independent of muscle weakness, skin lesions, osteoporosis, or neuropathy were observed in 23 (41.8%). Synovitis as reflected by pain, swelling, and effusion was observed in four patients, joint roentgenograms being negative. Thirteen experienced arthralgias; 12, diffuse musculoskeletal pain involving the lower extremities; 5, aseptic bone necrosis.
To investigate the possible role of immune mechanisms in the pathogenesis of these clinical findings, antibody activity against gamma globulin of human and foreign species origin was determined. Such
Bravo JF, Herman JH, Smyth CJ. Connective Tissue Disorders Following Renal Homotransplantation: A Clinical and Laboratory Analysis of 60 Cases.. Ann Intern Med. 1966;64:1166. doi: https://doi.org/10.7326/0003-4819-64-5-1166_2
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Published: Ann Intern Med. 1966;64(5):1166.
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