William McFarland, M.D., F.A.C.P.; Dorothy H. Heilman, M.D.; John F. Moorhead, M.D.
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As a result of recent progress in understanding of mechanisms of immunologic reactions including homograft rejection, the lymphocyte, a cell whose functions were little known a decade ago, has been assigned a major role. Particularly noteworthy from an investigative standpoint is the fact that the lymphocyte is capable of reacting not only in vivo but also in vitro to specific antigens and homologous cells, thus providing a model that promises to contribute significantly to knowledge at both the basic and clinical levels.
Time-lapse cinephotomicrographic studies of viable lymphocytes demonstrate a functional appendage on the lymphocyte, termed the "uropod," by which
McFarland W, Heilman DH, Moorhead JF. Current Observations of Lymphocyte Function: Relation to Clinical Problems.. Ann Intern Med. 1966;64:1166–1167. doi: https://doi.org/10.7326/0003-4819-64-5-1166_3
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Published: Ann Intern Med. 1966;64(5):1166-1167.
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