Joseph E. Sokal, M.D., F.A.C.P.
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Although glucagon is used clinically as a pharmacologic agent, its physiologic function and hormonal status have been subjects of controversy. Sufficient information is now available, however, to define an essential physiologic role for this polypeptide hormone.
Glucagon acts directly on the liver to stimulate both glycogenolysis and gluconeogenesis. Studies in this laboratory, using isolated perfused rat livers, have demonstrated both of these actions at glucagon concentrations well within the physiologic range; neither can be duplicated by physiologic concentrations of other biologic agents. Epinephrine, previously believed to stimulate hepatic glycogenolysis, has no direct effect on the liver except at concentrations far
Sokal JE. The Physiologic Function of Glucagon.. Ann Intern Med. 1966;64:1172–1173. doi: 10.7326/0003-4819-64-5-1172_3
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Published: Ann Intern Med. 1966;64(5):1172-1173.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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