Victor A. McKusick, M.D., F.A.C.P.; Robert A. Norum, M.D.; Henry J. Farkas, M.D.; Peter Brunt, M.B.; M. Mahloudji, M.D.
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Data have been collected on 102 families, each with at least 1 case of Riley-Day dysautonomia. In all but three sibships both parents have Jewish ancestry. In these three, one parent is apparently of non-Jewish ancestry in two instances, and both parents are non-Jewish in a third. In all except one couple the Jewish ancestry derived from Poland and neighboring Russia and Hungary; that of the other couple derived from Western Germany. All parents are normal. The proportion of siblings affected supports autosomal recessive inheritance. Consanguinity is known for five parental pairs. Birth order analysis suggests an influence on family
McKusick VA, Norum RA, Farkas HJ, Brunt P, Mahloudji M. Familial Dysautonomia: Genetic, Clinical and Pathophysiologic Studies.. Ann Intern Med. 1966;64:1175. doi: 10.7326/0003-4819-64-5-1175_1
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© 2019
Published: Ann Intern Med. 1966;64(5):1175.
DOI: 10.7326/0003-4819-64-5-1175_1
Neurology.
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