David Grob, M.D., F.A.C.P.
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The serum of the majority of patients with myasthenia gravis contains globulins that bind to components of normal cells, as demonstrated by immunofluorescent staining and complement fixation. In 62% of patients serum globulin bound to striations of normal skeletal muscle, in 15% to nuclei of muscle or calf thymic cells, and in 30% to cytoplasm of calf thymic epithelial cells. In 48% of patients serum globulin reacted with ribonucleo-protein obtained from normal muscle, as indicated by complement fixation. The incidence of these reactions was highest in patients with generalized myasthenia gravis of severe degree and of less than 3 year's
Grob D. Newer Aspects of Neuromuscular Disease.. Ann Intern Med. ;64:1175–1176. doi: 10.7326/0003-4819-64-5-1175_4
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Published: Ann Intern Med. 1966;64(5):1175-1176.
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