Henry T. Lynch, M.D.; Margery W. Shaw, M.D.; Charles W. Magnuson, M.D.; Arthur L. Larsen, M.D.; Anne J. Krush, M.S.
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Hereditary factors are clear in several types of malignancies, which include familial polyposis coli, retinoblastomas, xeroderma pigmentosum, neurofibromatosis, Gardner's syndrome, and the basal cell nevus syndrome. There is no simple genetic interpretation for most other carcinomas. Studies have shown, however, that there is a higher frequency of similar types of tumors in close relatives of propositi than is found in the general population. Studies made of five "cancer families" at the University of Nebraska are of interest from the following standpoints: (1) wide distribution of anatomic sites of the malignant neoplasms; (2) occurrence of malignancies through three and four generations
Lynch HT, Shaw MW, Magnuson CW, Larsen AL, Krush AJ. A Study of Five Cancer Families.. Ann Intern Med. ;64:1177–1178. doi: 10.7326/0003-4819-64-5-1177_3
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Published: Ann Intern Med. 1966;64(5):1177-1178.
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