Henry O. Heinemann, M.D.; Sue Buckingham, M.D.; Sheldon C. Sommers, M.D.
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It is now apparent that the mammalian lung is not solely concerned with the physical-chemical process of gas exchange but has other, nonrespiratory, functions. One of these functions, which has attracted considerable interest in recent years, is the synthesis of lipids. The ability of lung tissue to synthesize lipids has been established by a variety of investigators in the rat, rabbit, dog, and guinea pig. In vivo and in vitro studies in rabbits utilizing various radioactive isotope-labeled precursors have demonstrated that lung tissue can utilize glucose, lactate, pyruvate, palmitate and especially acetate for the preferential formation of phospholipids, specifically lecithin.
Heinemann HO, Buckingham S, Sommers SC. Phospholipid Synthesis by Mammalian (Rabbit) Lung Tissue.. Ann Intern Med. 1966;64:1180. doi: 10.7326/0003-4819-64-5-1180_2
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Published: Ann Intern Med. 1966;64(5):1180.
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