John R. Gill Jr., M.D., F.A.C.P.; Dean H. Mason, M.D. (Associate); Frederic C. Bertter, M.D.
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Amphetamine and hydroxyamphetamine (Paredrine®) reportedly increase sodium excretion in patients with idiopathic edema. These compounds, given intravenously, increase circulating catecholamines, and their natriuretic effects have been attributed to their vasoconstrictor properties. The present studies demonstrate the natriuretic effects and suggest an additional action for these compounds. The sodium-retaining steroid, 2-methyl-9 alpha-fluorohydrocortisone was given for 4 to 7 days to five patients on constant diets containing 250 mEq of sodium/day, and cumulative sodium retention was determined. After treatment with hydroxyamphetamine for 10 to 12 days (maximal dose, 400 mg/day), the steroid was readministered for the same length of time as in
Gill JR, Mason DH, Bertter FC. Studies of the Natriuresis of Hydroxyamphetamine and on Its Mechanism of Action.. Ann Intern Med. 1966;64:1185. doi: https://doi.org/10.7326/0003-4819-64-5-1185_1
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Published: Ann Intern Med. 1966;64(5):1185.
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