JEROME I. BRODY, M.D., F.A.C.P.; LAWRENCE H. BEIZER, M.D., F.A.C.P.
The purpose of this investigation was to evaluate the immune reactivity of the neoplastic lymphocyte in chronic lymphocytic leukemia by characterizing the response of patients with this blood dyscrasia to a polyvalent Salmonella antigen. The knowledge that 19S macroglobulin antibody (γM, IgM) is synthesized in part by the normal lymphocyte and represents a major initial defense against gram-negative septicemia (1, 2) and the failure of patients with lymphoproliferative disorders to successfully withstand such infections (3) implied that the leukemic lymphocyte may have lost an important biosynthetic function.
There have been a number of difficulties associated with studying the dynamics of
BRODY JI, BEIZER LH. Immunologic Incompetence of the Neoplastic Lymphocyte in Chronic Lymphocytic Leukemia. Ann Intern Med. ;64:1237–1245. doi: 10.7326/0003-4819-64-6-1237
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Published: Ann Intern Med. 1966;64(6):1237-1245.
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