THOMAS N. JAMES, M.D., F.A.C.P.
Amyloidosis often involves the heart, and experienced clinicians have learned to suspect this disease in any patient presenting with unexplained cardiac enlargement or cardiac failure. Atrial fibrillation and other arrhythmias as well as various degrees of heart block are frequent manifestations of cardiac amyloidosis (1-12). Examinations of the cardiac conduction system seldom have been reported in amyloidosis, however, and may be negative (13, 14). Since amyloid commonly deposits in the coronary arteries (12, 15), functional disturbances in cardiac rhythm and conduction might be due to ischemia in the critical conduction centers secondary to amyloid in the arteries. Similarly, since amyloid
JAMES TN. Pathology of the Cardiac Conduction System in Amyloidosis. Ann Intern Med. 1966;65:28–36. doi: 10.7326/0003-4819-65-1-28
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Published: Ann Intern Med. 1966;65(1):28-36.
Cardiology, Rhythm Disorders and Devices.
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