DONALD S. MILLER, M.D.; CHARLES E. MENGEL, M.D.; WILLIAM B. KREMER, M.D.; JORDAN GUTTERMAN, M.D.; RON SENNINGEN
The in vivo role of mechanical factors as a cause of increased destruction of red blood cells has received greater attention recently. This phenomenon was implied by Brain, Dacie, and Hourihane (1) in their studies of patients with bizarre red cells in the setting of small blood vessel disease and the term "microangiopathic hemolytic anemia" was coined. Mechanical factors were also thought to play a role in the hemolysis that has been reported after the implantation of aortic valve prosthesis (2-4). Recently, it has been suggested that damaged, distorted valves, and the accompanying hemodynamic alterations, per se, may cause unusual
MILLER DS, MENGEL CE, KREMER WB, et al. Intravascular Hemolysis in a Patient with Valvular Heart Disease. Ann Intern Med. 1966;65:210–215. doi: 10.7326/0003-4819-65-2-210
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Published: Ann Intern Med. 1966;65(2):210-215.
Cardiology, Valvular Heart Disease.
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