PATRICIA WILKINSON, M.D., F.R.C.P.; WARREN DAVIDSON, M.D.; AMORY SOMMARIPA, M.D.
In Waldenström's macroglobulinemia (1) turnover of the patient's own abnormal macroglobulin has been measured only in untreated patients (2-5) or in patients who have been plasmapheresed (5). There are no reports of turnover of anomalous macroglobulin after cytotoxic therapy. We were recently able to measure the turnover of the abnormal macroglobulin after labeling it with 131I in a patient with Waldenström's macroglobulinemia who was receiving phenylalanine mustard. Although we were unable to study him before therapy, it seemed worthwhile to investigate his turnover of macroglobulin when remission had been obtained with the drug, in the hope of learning more about
WILKINSON P, DAVIDSON W, SOMMARIPA A. Turnover of 131I-labeled Autologous Macroglobulin in Waldenström's Macroglobulinemia: Report of a Case Studied During Treatment with Phenylalanine Mustard. Ann Intern Med. ;65:308–316. doi: 10.7326/0003-4819-65-2-308
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Published: Ann Intern Med. 1966;65(2):308-316.
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