J. WAYNE STREILEIN, M.D.; E. A. HILDRETH, M.D., F.A.C.P.; H. RAMSEIER, D.SCI.; J. KORNBLUM, M.D.
In a previous report (1), it was shown that homologous rodent lymphoid cell mixtures of binary origin1 evoke delayed reactions when injected intracutaneously in irradiated hamsters. The intensities of these reactions appeared to be related to the degree of immunogenetic disparity between the cell donors as revealed by the survival times of skin homografts exchanged between members of the strains concerned.
These empiric observations suggested that, if mixtures of human lymphoid cells behave in a similar manner when injected intracutaneously into irradiated hamsters, their reactions might furnish the basis of a means of donor selection for homotransplantation in man. Experimental
STREILEIN JW, HILDRETH EA, RAMSEIER H, KORNBLUM J. The Irradiated Hamster Test: A New Method of Donor Selection for Homotransplantation in Man. Ann Intern Med. ;65:511–520. doi: 10.7326/0003-4819-65-3-511
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Published: Ann Intern Med. 1966;65(3):511-520.
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