HERVEY P. BRITTAIN, M.D.; ANGEL DE LA TORRE, M.D.; EDWARD N. WILLEY, M.D.
Abnormalities of hepatic function are frequently observed in patients with sickle cell hemoglobinopathy (1-5). Such abnormalities include increased direct-acting serum bilirubin, bilirubinuria, urobilinogenuria, decreased Bromsulphalein® excretion, increased serum alkaline phosphatase, increased serum glutamic oxaloacetic transaminase, prolonged prothrombin time, hypoalbuminemia, hyperglobulinemia, and increased cephalin flocculation or thymol turbidity tests. These manifestations of hepatic dysfunction appear to be due to hepatic ischemia caused by obstruction of sinusoids by sickled red cells (1, 3, 6, 7). Both in biopsy and in autopsy material intralobular necrosis and scattered confluent lobular infarcts have been reported by various authors (1, 2, 3, 7). Extensive confluent lobular
BRITTAIN HP, DE LA TORRE A, WILLEY EN. A Case of Sickle Cell Disease with an Abscess Arising in an Infarct of the Liver. Ann Intern Med. 1966;65:560–563. doi: 10.7326/0003-4819-65-3-560
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Published: Ann Intern Med. 1966;65(3):560-563.
Hematology/Oncology, Infectious Disease, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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