JAMES S. ADAMSON JR., M.D.; WILLIAM J. FLANIGAN, M.D.; GEORGE L. ACKERMAN, M.D.
Although bromides are rarely prescribed as sedatives or anticonvulsants, bromide intoxication remains a significant clinical problem because the drug is readily available in nonprescription compounds. In a recent study it was found that 10% of patients admitted to a psychiatric hospital had detectable blood bromide levels, and 2% were considered to have clinically significant bromism (1). For this latter group prolonged hospitalization is required, and death occurs in rare instances. In patients with severe toxic manifestations numerous means of therapy have been used, including salt loading (2), diuretics (3), gastric aspiration (4), and hemodialysis (5, 6). This paper reports the
ADAMSON JS, FLANIGAN WJ, ACKERMAN GL. Treatment of Bromide Intoxication with Ethacrynic Acid and Mannitol Diuresis. Ann Intern Med. ;65:749–752. doi: 10.7326/0003-4819-65-4-749
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Published: Ann Intern Med. 1966;65(4):749-752.
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