ALLAN J. ERSLEV, M.D.
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It is generally accepted that the control of red cell production is influenced by erythropoietin and by the tissue tension of oxygen. Clinical observations on patients in whom a reverse blood flow through a patent ductus arteriosus has caused a localized subdiaphragmatic hypoxia (1) and experimental observations on the kidneys (2) have led to the hypothesis that red cell production is regulated solely by the release of renal erythropoietin, which in turn is regulated by the renal tissue tension of oxygen. However, the persistence of red cell production in anephric man (3) and the fact that the kidney, because of
ERSLEV AJ. Hypothalamic Control of Red Cell Production. Ann Intern Med. ;65:862–863. doi: 10.7326/0003-4819-65-4-862
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Published: Ann Intern Med. 1966;65(4):862-863.
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