SALMAN GAILANI, M.B.; AUGUSTINE L. ROQUE, M.D.; JAMES F. HOLLAND, M.D.
Carcinoid syndrome produced by metastatic bronchial adenoma is a rare but a well-established entity (1). Although the role of serotonin in the production of the carcinoid flush has been disputed recently (2, 3), elevated blood serotonin and increased excretion of its metabolite (5-hydroxyindolacetic acid (5-HIAA)) are still the most consistent measurable parameters in this condition. This paper presents the report of a patient with carcinoid syndrome caused by metastatic bronchial adenoma in whom definite symptomatic improvement was achieved by interference with serotonin synthesis. This interference was accomplished by production of a vitamin B6 deficiency state during prolonged ingestion of a
GAILANI S, ROQUE AL, HOLLAND JF. The Effect of Pyridoxine Deficiency on Carcinoid Syndrome: Study of a Case of Metastatic Bronchial Adenoma Treated with Induced Vitamin B6 Deficiency. Ann Intern Med. 1966;65:1044–1050. doi: https://doi.org/10.7326/0003-4819-65-5-1044
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Published: Ann Intern Med. 1966;65(5):1044-1050.
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