MYRON R. SCHOENFELD, M.D., F.A.C.P.; STEPHEN GULOTTA, M.D.
The most common pathologic findings (hematoxylin and eosin stain) in the human nephron in hypokalemic nephropathy are vacuolization or granulation or both of proximal convoluted tubules, distal tubules being less affected (1-3); this is a pattern apparently constant regardless of the cause of potassium loss. The nature of these vacuoles and granules is not clear. Because staining techniques have shown that they do not contain glycogen or lipid and because potassium depletion in experimental animals often increases the number of renal lysosomes (1-3), it has been suggested that perhaps they are lysosomes.
The admission of a patient with hypokalemia associated
SCHOENFELD MR, GULOTTA S. Renal Tubular Acidosis, Hypokalemia, and Acid Phosphatase. Ann Intern Med. ;65:1256–1259. doi: 10.7326/0003-4819-65-6-1256
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Published: Ann Intern Med. 1966;65(6):1256-1259.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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