JOHN B. DOSSETOR, M.D., PH.D., F.A.C.P., F.R.C.P. (C)
The terms uremia and azotemia are applied to acute or chronic conditions in which the blood concentration of nitrogenous end products rises. The terms are otherwise poorly defined. Nitrogen retention usually occurs when the renal function is less than 30% of normal. Recently, progressive renal dysfunction has been graded as  diminished renal reserve,  renal insufficiency,  renal failure, and  uremia (Strauss and Welt (1) 1963), but each grade overlaps others.
Although urea is present in greatest amount, errors can occur when increased urea concentration is accepted as synonymous with the degree of renal dysfunction. Myers, Fine, and
DOSSETOR JB. Creatininemia Versus Uremia: The Relative Significance of Blood Urea Nitrogen and Serum Creatinine Concentrations in Azotemia. Ann Intern Med. 1966;65:1287–1299. doi: 10.7326/0003-4819-65-6-1287
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Published: Ann Intern Med. 1966;65(6):1287-1299.
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