ARNO G. MOTULSKY, M.D.; GEORGE STAMATOYANNOPOULOS, M.D.
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The clinical significance of the deficiency of red-cell glucose-6-phosphate dehydrogenase (G-6-PD) was realized when this enzymatic abnormality was found to be the basic lesion responsible for hemolytic reactions precipitated by the antimalarial drug primaquine (1). The introduction of simple diagnostic techniques facilitated clinical and population studies and made clinicians aware of the extent of this abnormality. It is now known that more than 100 million people have G-6-PD deficiency. The anomaly is genetically transmitted as a sex-linked trait. It is fully expressed in males carrying a single dose of the abnormal gene (hemizygotes) as well as in females carrying a
MOTULSKY AG, STAMATOYANNOPOULOS G. Clinical Implications of Glucose-6-Phosphate Dehydrogenase Deficiency. Ann Intern Med. ;65:1329–1334. doi: 10.7326/0003-4819-65-6-1329
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Published: Ann Intern Med. 1966;65(6):1329-1334.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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