JAMES V. DONADIO JR., M.D.; CHARLES D. FARMER, M.D.; JAMES C. HUNT, M.D., F.A.C.P.; W. NEWLON TAUXE, M.D.; GEORGE A. HALLENBECK, M.D.; ROY G. SHORTER, M.D.
In patients with renal allografts, serial determinations of renal function are of prognostic significance. Trends in renal function may be considered as reflecting a balance between effective immunosuppressive therapy on one hand, and the immunologic response—that is, the rejection process—on the other (1). A stable or upward trend in renal function indicates that rejection is being successfully controlled. A downward trend indicates the need for increased immunosuppressive therapy, if mechanical obstructive and infectious causes have been eliminated.
An important aspect in the long-term care of these patients is to establish an optimal antirejection drug program; and, as a proper guideline
DONADIO JV, FARMER CD, HUNT JC, TAUXE WN, HALLENBECK GA, SHORTER RG. Renal Function in Donors and Recipients of Renal Allotransplantation: Radioisotopic Measurements. Ann Intern Med. 1967;66:105–115. doi: 10.7326/0003-4819-66-1-105
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Published: Ann Intern Med. 1967;66(1):105-115.
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