G. F. CAHILL JR., M.D.
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In a recent communication, scientists at the Jackson Laboratory in Bar Harbor, Me., reported a mutation (db) in an inbred strain of mice which is inherited as an autosomal-recessive trait and, when homozygous, is characterized by a syndrome resembling diabetes mellitus in man (1). Other diabetic syndromes, usually associated with obesity, have been described in mice, such as the obese-hyperglycemic gene (ob) that results, in the homozygous animal, in a syndrome with minimal hyperglycemia and marked obesity, or the yellow or agouti gene (Ay), which is inherited as a dominant trait and is lethal when homozygous.
In contrast to these
CAHILL GF. Diabetes Mellitus in Man and Experimental Animals. Ann Intern Med. ;66:227–230. doi: 10.7326/0003-4819-66-1-227
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Published: Ann Intern Med. 1967;66(1):227-230.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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