ERIC EISNER, M.D.; ALLYN B. LEY, M.D.; KLAUS MAYER, M.D., F.A.C.P.
Anemia, more or less severe in intensity, occurs in the course of nearly all cases of Hodgkin's disease. Although the dominant defect is usually one of insufficient red cell production, a decreased erythrocyte life-span has been demonstrated in a number of studies (1-5); indeed, a recent report (6) suggests that a significantly shortened red cell survival is characteristic of the advanced stages of the disease. The mechanism of this increased rate of cell destruction is not known. The classical manifestations of hemolytic anemia are scant or absent. Evidences of markedly increased hemoglobin catabolism and of intense erythropoiesis are usually not
EISNER E, LEY AB, MAYER K. Coombs'-positive Hemolytic Anemia in Hodgkin's Disease. Ann Intern Med. ;66:258–273. doi: 10.7326/0003-4819-66-2-258
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Published: Ann Intern Med. 1967;66(2):258-273.
Hematology/Oncology, Leukemia/Lymphoma, Red Cell Disorders.
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