RANDOLPH M. MCCLOY, M.D.; WILLIAM P. BALDUS, M.D.; W. NEWLON TAUXE, M.D.; W. H. J. SUMMERSKILL, M.D., F.A.C.P.
Diminutions in plasma volume (1-6) or effective extracellular fluid volume (7-12) have been proposed as explanations for renal circulatory failure in patients with cirrhosis. Hori, Austen, and McDermott (4) and Lieberman and Reynolds (6) attributed the decrease in glomerular filtration rate to hypovolemia, and Vesin (1) believed that plasma volume is never increased and is usually low in such patients. In a later article with Traverso and colleagues (2) that described eight patients with low creatinine clearances, Vesin did not indicate whether the plasma volumes reported were normal.
However, when plasma volume was measured in patients with cirrhosis (13-19), including
MCCLOY RM, BALDUS WP, TAUXE WN, SUMMERSKILL WHJ. Plasma Volume and Renal Circulatory Function in Cirrhosis. Ann Intern Med. ;66:307–311. doi: 10.7326/0003-4819-66-2-307
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Published: Ann Intern Med. 1967;66(2):307-311.
Gastroenterology/Hepatology, Liver Disease, Nephrology.
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