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In 1958, the recovery after bone marrow transplantation by four out of five patients from accidental total body irradiation provoked a great deal of interest in applying this technique to other problems, especially those dealing with hematology and oncology. A large amount of clinical work was done, often before some of the fundamental radiobiological and hematological problems had been worked out. With the passage of time much less clinical work has been done with bone marrow transplantation, although certain clinical applications are of persistent interest as are some of the associated biological phenomena such as graft-versus-host reactions and immunological chimerism.
Bone Marrow Transplantation.. Ann Intern Med. ;66:455. doi: 10.7326/0003-4819-66-2-455_1
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Published: Ann Intern Med. 1967;66(2):455.
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