WILLIAM R. HARLAN JR., M.D.; ALBERT OBERMAN, M.D.; ROBERT E. MITCHELL, M.D.; ASHTON GRAYBIEL, M.D.
Despite the important association between elevated plasma lipids and the development of coronary heart disease, there is a surprising lack of information relating plasma lipid levels to specific genetic and environmental factors. The striking differences in plasma lipids among populations with environments that are widely divergent are readily explained by dietary and other ecological differences. However, these factors are relatively homogenous within population groups, particularly in this country, and individual differences in lipid levels cannot be explained by ecological differences. Constitutional and environmental factors are primarily responsible for these differences (1-3), but few of these have been identified and quantified
HARLAN WR, OBERMAN A, MITCHELL RE, et al. Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein Levels. Ann Intern Med. 1967;66:540–555. doi: https://doi.org/10.7326/0003-4819-66-3-540
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Published: Ann Intern Med. 1967;66(3):540-555.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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