SANDER J. ROBINS, M.D.; MARIO GARCIA-PALMIERI, M.D., F.A.C.P.; CARLOS RUBIO, M.D.
During the initial months of a prospective epidemiologic investigation of coronary heart disease in middle-aged Puerto Rican men, it was readily apparent that subjects with low serum cholesterol values were being encountered with unusual frequency. Of the first 2,000 individuals examined, 49% had cholesterol values below 200 mg/100 ml, and 12% had values less than 160 mg/100 ml (1).
A malabsorption syndrome of undetermined cause (tropical sprue) has remained endemic in Puerto Rico since recognized 60 years ago. Series of patients with sprue have been regularly reported with low mean serum cholesterol values, and the impression exists that these individuals
ROBINS SJ, GARCIA-PALMIERI M, RUBIO C. Low Serum Cholesterol Levels and Subclinical Malabsorption. Ann Intern Med. 1967;66:556–567. doi: https://doi.org/10.7326/0003-4819-66-3-556
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Published: Ann Intern Med. 1967;66(3):556-567.
Cardiology, Celiac Disease and Malabsorption, Coronary Risk Factors, Dyslipidemia, Gastroenterology/Hepatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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