FREDERICK L. BENOIT; FRANCIS S. GREENSPAN, M.D., F.A.C.P.
Treatment of pretibial myxedema, the enigmatic skin lesion associated with hyperthyroidism, has been only sporadically successful, despite the utilization of various therapeutic modalities. Corticoids, one group of medications used, have given widely variable results. In the first report mentioning steroid therapy systemic cortisone was given to counteract the activity of locally injected hyaluronidase, and it was noted that the pretibial lesions disappeared completely (1). Although some subsequent reports confirmed this observation (2-5), many others recorded no improvement after giving systemic steroids in a wide range of dosages (6-15). Similarly, the effect of their local application to the lesion, either by
BENOIT FL, GREENSPAN FS. Corticoid Therapy for Pretibial Myxedema: Observations on the Long-acting Thyroid Stimulator. Ann Intern Med. ;66:711–720. doi: 10.7326/0003-4819-66-4-711
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Published: Ann Intern Med. 1967;66(4):711-720.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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