Max Samter, M.D., F.A.C.P.
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It is known that eosinophils appear as an aftermath of anaphylaxis in sensitized tissues that are reexposed to specific antigens. Circumstantial evidence that has accumulated in recent years makes it likely that they participate in the disposal of the antigen-antibody complex.
Our observations on guinea pigs indicate (1) that the initial injection of antigenic material directly into the lung induces a marked eosinophilia at the site of injection within 72 hr, (2) that at the time—in contrast to generalized anaphylaxis—there is no correlation between eosinophilia in the lung and the titer of circulating eosinophils (which remains stable), and (3) that
Samter M. Eosinophils in the Immunology of Anaphylaxis.. Ann Intern Med. ;66:1027. doi: 10.7326/0003-4819-66-5-1027_1
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Published: Ann Intern Med. 1967;66(5):1027.
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