M. D. Turner, M.D.; G. O. Garrido-Pinson, M.D.; I. Michael Samloff, M.D.; Harry L. Segal, M.D., F.A.C.P.
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Previous studies from this and other laboratories have shown evidence for the existence of two distinct types of autoantibody to human intrinsic factor in the sera of some patients with pernicious anemia.
The antibodies vary in amount independently of one another. The first type of antibody ("blocking" antibody) reacts with intrinsic factor to prevent subsequent formation of the B12-intrinsic factor complex. The antibody is incapable of reacting with the preformed intrinsic factor-B12 complex and does not displace the vitamin B12 from such a complex. This antibody is detected by the charcoal adsorption assay. The second type ("binding" antibody) reacts either
Turner MD, Garrido-Pinson GO, Samloff IM, Segal HL. Studies of Human Intrinsic Factor Auto-Antibodies.. Ann Intern Med. ;66:1027. doi: 10.7326/0003-4819-66-5-1027_2
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Published: Ann Intern Med. 1967;66(5):1027.
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