Lowell L. Sparks, M.D.; Jerry M. Earll; Michael Tuck, M.D.; Peter H. Forsham, M.D., F.A.C.P.; Donald E. McMillan, M.D.
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Fourteen patients with active acromegaly were studied before and after treatment with cryohypophysectomy. Serum immunoreactive human growth hormone (IRHGH) is the most direct method available for diagnosis. Because of the physiologic lability of IRHGH, especially in women, fasting levels do not allow clear separation between normal and acromegalic subjects. Acromegalics tend to have fixed levels of IRHGH throughout the day and often do not respond normally to insulin hypoglycemia or intravenous arginine stimulation. The best separation, however, is obtained with glucose suppression of IRHGH. Sixty minutes after a standard oral glucose tolerance test 8 normals suppressed to less than 1
Sparks LL, Earll JM, Tuck M, et al. Critical Factors in the Diagnosis of Active Acromegaly.. Ann Intern Med. 1967;66:1029. doi: https://doi.org/10.7326/0003-4819-66-5-1029_1
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Published: Ann Intern Med. 1967;66(5):1029.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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