Oscar Bodansky, M.D., Ph.D.; Morton K. Schwartz, Ph.D.; Martin L. Feingold, M.D.; C. S. Song, M.D.
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5′-Nucleotidase activity, mediating the liberation of inorganic phosphate from 5′-nucleotides, has been known to be present in human tissues, and its elevation in serum has been previously reported to indicate hepatobiliary disease. The present communication reviews recent work in this laboratory on the purification of this enzyme from human liver and on the comparison of its kinetic properties with those of the enzyme from bull semen and from rat liver. By means of techniques for isolating subcellular structural components in a state free from crosscontamination, 5′-nucleotidase of the rat liver was shown to be localized in the membranous component of
Bodansky O, Schwartz MK, Feingold ML, et al. Biochemical Characteristics of 5′-Nucleotidase and Diagnostic Utilization of Its Activity in Human Serum.. Ann Intern Med. 1967;66:1031. doi: 10.7326/0003-4819-66-5-1031_1
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Published: Ann Intern Med. 1967;66(5):1031.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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